Probenecid inhibition of the renal excretion of dyphylline in chicken, rat and man
| Autor: | E. N. Terry, M. Acara, E. A. Carr |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Metabolic Clearance Rate Pharmaceutical Science Biology Kidney urologic and male genital diseases Excretion Dyphylline Theophylline Pharmacokinetics Internal medicine medicine Animals Humans Carbon Radioisotopes Pharmacology Probenecid Rats Perfusion medicine.anatomical_structure Endocrinology Excretory system Renal physiology Organic anion transport Chickens Half-Life medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 39:526-530 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1987.tb03171.x |
| Popis: | The effect of probenecid on the renal excretion of dyphylline was studied in chicken, rat and man. Dyphylline was found to be actively excreted when measured by the Sperber preparation in hens, the isolated perfused kidney of the rat and clearance studies in man. In each study probenecid significantly decreased dyphylline excretion demonstrating that dyphylline occupied the renal organic anion transport system. This same drug interaction, at the level of the renal excretory system, in these three species occurred at comparable concentrations of dyphylline and probenecid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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