Novel method for kinetic analysis applied to transport by the uniporter OCT2

Autor:	Stephen Wright, Timothy Secomb
Rok vydání:	2022
Předmět:	Kinetics Cricetulus Physiology Cricetinae Animals Water Biological Transport CHO Cells
Zdroj:	American Journal of Physiology-Renal Physiology. 323:F370-F387
ISSN:	1522-1466 1931-857X
DOI:	10.1152/ajprenal.00106.2022
Popis:	The kinetics of solute transport shed light on the roles these processes play in cellular physiology, and the absolute values of the kinetic parameters that quantitatively describe transport are increasingly used to model its impact on drug clearance. However, accurate assessment of transport kinetics is challenging. Although most carrier-mediated transport is adequately described by the Michaelis-Menten equation, its use presupposes that the rates of uptake used in the analysis of maximal rates of transport (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca8977f3e7e4ed607fa7fec696783ce https://doi.org/10.1152/ajprenal.00106.2022 Zobrazit plný text záznamu