Urothelial dysfunction and sensory protein expressions in patients with urological or systemic diseases and hypersensitive bladder
| Autor: | Hueih-Ling Ong, Hann-Chorng Kuo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Urology 030232 urology & nephrology urologic and male genital diseases lcsh:RC870-923 sensory receptor 03 medical and health sciences Bladder outlet obstruction 0302 clinical medicine Diabetes mellitus Medicine Urothelium Spinal cord injury bladder detrusor business.industry Interstitial cystitis urothelium medicine.disease bladder disorder lcsh:Diseases of the genitourinary system. Urology Pathophysiology female genital diseases and pregnancy complications Overactive bladder 030220 oncology & carcinogenesis Bladder Disorder business |
| Zdroj: | Urological Science, Vol 28, Iss 3, Pp 128-134 (2017) |
| ISSN: | 1879-5226 |
| Popis: | Objective To investigate the underlying pathophysiology in the urothelium of different lower urinary tract diseases (LUTDs) and in patients with overactive bladder (OAB) or hypersensitive bladder (HSB), including chronic inflammation, barrier proteins, and sensory functional receptors. Materials and Methods A total of 156 patients, including 14 with idiopathic OAB, 11 with detrusor overactivity and inadequate contractility (DHIC), 19 with end-stage renal disease (ESRD) and HSB, 26 with spinal cord injury (SCI) and detrusor overactivity (DO), 23 with bladder outlet obstruction (BOO) and DO, 19 with diabetes mellitus (DM) and OAB, 20 with interstitial cystitis (IC), and 24 with ketamine cystitis (KC) were investigated for urothelial dysfunction and sensory protein expressions. Twenty control patients without LUTD were invited and separated into two groups for comparative studies. All participants had urodynamically proven DO or increased bladder sensation on video urodynamic studies. Urothelial dysfunction and functional receptor expressions were investigated and compared between patients with LUTD and controls. Results All patient subgroups had significant increases in mast cell activation and apoptotic cell counts and a decrease in E-cadherin expression. P2X3 expression was significantly decreased in DHIC but was increased in BOO/DO. Urothelial M3 expression was significantly increased in patients with OAB, BOO/DO, DM/OAB, and KC. M2 expression was significantly decreased in DHIC but increased in patients with BOO/DO. β3-AR expression was significantly decreased in patients with OAB and increased in patients with DHIC, ESRD/HSB, DM/OAB, and KC. Patients with OAB and BOO/DO had significantly increased M2/β3-AR. Lower M2/β3-AR was associated with lower voiding efficiency and large postvoid residual (PVR) in DHIC, ESRD/HSB, and SCI/neurogenic detrusor overactivity (NDO). Conclusion Patients with OAB or HSB showed increased urothelial inflammation and lower barrier protein expression. Increased M3/β3-AR or M2/β3-AR in the urothelium was associated with OAB, whereas decreased M3/β3-AR or M2/β3-AR was associated with poor voiding efficiency and large PVR in LUTD. |
| Databáze: | OpenAIRE |
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