Sequential Regioselective Diorganochalcogenations of Imidazo[1,2- a ]pyrimidines Using I 2 /H 3 PO 4 in Dimethylsulfoxide
| Autor: | Anne Roly Obah Kosso, Patrice Vanelle, Youssef Kabri, Julie Broggi, Sébastien Redon |
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| Přispěvatelé: | Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pyrimidine
010405 organic chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry Regioselectivity chemistry.chemical_element 010402 general chemistry Iodine 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Surface modification ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Journal of Organic Chemistry Journal of Organic Chemistry, American Chemical Society, 2020, 85 (5), pp.3071-3081. ⟨10.1021/acs.joc.9b02963⟩ Journal of Organic Chemistry, 2020, 85 (5), pp.3071-3081. ⟨10.1021/acs.joc.9b02963⟩ |
| ISSN: | 0022-3263 1520-6904 |
| Popis: | The dichalcogenation of imidazoheterocycles led to the first functionalization of imidazo[1,2-a]pyrimidine cores on the C6-position. The methodology, involving iodine/dimethylsulfoxide oxidation of diaryldichalcogenides, started with C3-chalcogenation, followed by C6 selanylation, activated in acidic medium. This novel sequential dichalcogenation strategy proceeded efficiently with excellent regioselectivity and yields. |
| Databáze: | OpenAIRE |
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