Protection from gastrointestinal side-effects by azapropazone by its incorporation into a glucose-sodium acid citrate formulation
| Autor: | J. F. Hort, K. D. Rainsford, R. Upadhyay, R. I. Russell, Paul Dieppe, H. Leach, John Rhodes, F. S. Walker, M. H. Pritchard |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Apazone Male Peptic Ulcer medicine.medical_specialty Adolescent Pharmacology Citric Acid Endoscopy Gastrointestinal Arthritis Rheumatoid chemistry.chemical_compound Pharmacokinetics Internal medicine Sodium citrate medicine Gastric mucosa Animals Humans Single-Blind Method Pharmacology (medical) Citrates Azapropazone Aged Hepatology Red Cell business.industry Stomach Gastroenterology Rats Inbred Strains Middle Aged Rats Glucose medicine.anatomical_structure Endocrinology chemistry Gastric Mucosa Toxicity Female Citric acid business medicine.drug |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 5:419-433 |
| ISSN: | 1365-2036 0269-2813 |
| DOI: | 10.1111/j.1365-2036.1991.tb00046.x |
| Popis: | Addition of glucose and sodium citrate to azapropazone, in proportions of 1:1:1 by weight reduced gastric mucosal damage in rats and there was a trend towards reduction in radiolabelled faecal red cell loss in human volunteers compared with that with azapropazone alone. The glucose and citrate did not affect the pharmacokinetics of azapropazone, or its therapeutic efficacy. While no difference was observed in endoscopic injury and in symptomatic gastrointestinal complaints in a multicentre comparison in rheumatic patients, a striking reduction in symptoms was observed in those patients with a history of severe gastrointestinal intolerance to non-steroidal anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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