Cortical hyper-excitability in healthy children: evidence from habituation and recovery cycle phenomena of somatosensory evoked potentials
| Autor: | Lucia Martucci, Domenico Restuccia, Sergio Zanini, Ivana Del Piero |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Aging medicine.medical_specialty Adolescent Stimulation Electroencephalography Audiology Stimulus (physiology) Somatosensory system 03 medical and health sciences 0302 clinical medicine Neurochemical Developmental Neuroscience Evoked Potentials Somatosensory medicine Humans Habituation Child Habituation Psychophysiologic medicine.diagnostic_test Recovery of Function Somatosensory Cortex Middle Aged Electric Stimulation Healthy Volunteers Median Nerve Settore MED/26 - NEUROLOGIA 030104 developmental biology medicine.anatomical_structure Cerebral cortex Somatosensory evoked potential Child Preschool Cortical Excitability Pediatrics Perinatology and Child Health recovery cycle Female Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Developmental Medicine & Child Neurology. 58:855-860 |
| ISSN: | 0012-1622 |
| DOI: | 10.1111/dmcn.13072 |
| Popis: | Aim To compare neurophysiological parameters of central nervous system excitability in healthy children/adolescents with those of healthy adults. Method Two experimental protocols were used in 19 healthy children/adolescents (10 males and 9 females, mean age 9y 11mo [SD 2y 9mo], range 5–15y) and 19 healthy adults (8 males and 11 females, mean age 36y 6mo [SD 7y 9mo], range 27–51y). First, we administered repetitive trains of innocuous electrical stimulation of the median nerve and analysed habituation (progressive attenuation) of the cervical and cortical responses. Second, we administered several blocks of two closely timed electrical innocuous stimuli of the median nerve (with interstimulus intervals set at 5, 10, and 20ms in each block) and analysed the recovery index (the percentage of the response to the second stimulus with respect to that to the first). Results Clear-cut neurophysiological signs of cortical hyper-excitability were found in children/adolescents but not in adults. In contrast with the adults, the children/adolescents did not attenuate cortical responses to repetitive stimulation, and presented with extremely shortened recovery cycle. At baseline, both groups presented with comparable cortical responses. Interpretation Healthy children/adolescents present cortical hyper-excitability compared with healthy adults. These findings agree with previous findings that show an overall imbalance of excitatory and inhibitory neuronal and neurochemical mechanisms in favour of excitatory ones, in the healthy developing cerebral cortex. |
| Databáze: | OpenAIRE |
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