Synergies with and Resistance to Membrane-Active Peptides
| Autor: | Adam Kmeck, Cristina R. Ventura, Robert J. Tancer, Gregory Wiedman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) drug synergy Resistance (ecology) Chemistry 030106 microbiology lcsh:RM1-950 Review Computational biology antimicrobial-resistance Biochemistry Microbiology 03 medical and health sciences 030104 developmental biology Infectious Diseases Membrane Antibiotic resistance lcsh:Therapeutics. Pharmacology Synergy Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics membrane-active peptides |
| Zdroj: | Antibiotics, Vol 9, Iss 620, p 620 (2020) Antibiotics |
| ISSN: | 2079-6382 |
| Popis: | Membrane-active peptides (MAPs) have long been thought of as the key to defeating antimicrobial-resistant microorganisms. Such peptides, however, may not be sufficient alone. In this review, we seek to highlight some of the common pathways for resistance, as well as some avenues for potential synergy. This discussion takes place considering resistance, and/or synergy in the extracellular space, at the membrane, and during interaction, and/or removal. Overall, this review shows that researchers require improved definitions of resistance and a more thorough understanding of MAP-resistance mechanisms. The solution to combating resistance may ultimately come from an understanding of how to harness the power of synergistic drug combinations. |
| Databáze: | OpenAIRE |
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