A biomarker for lymphoma development in Sjogren's syndrome: Salivary gland focus score
| Autor: | L. Chatzis, Dimitrios I. Fotiadis, Paraskevi V. Voulgari, Athanasios G. Tzioufas, M. Voulgarelis, Salvatore De Vita, Valentina Donati, Haralampos M. Moutsopoulos, V. Pezoulas, Vasilis Gorgoulis, Andreas V. Goules, Chiara Baldini, Clio P. Mavragani, Fotini N. Skopouli, Saviana Gandolfo, Efstathia K. Kapsogeorgou, Themis P. Exarchos |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Time Factors Focus score Lymphoma Biopsy Logistic regression Gastroenterology Serology Disease phenotypes 0302 clinical medicine immune system diseases Risk Factors hemic and lymphatic diseases Immunology and Allergy Labial minor salivary gland biopsy Early Detection of Cancer Aged 80 and over Salivary gland Middle Aged Cryoglobulinemia medicine.anatomical_structure Sjogren's Syndrome Cohort Biomarker (medicine) Female Sjögren's syndrome Adult medicine.medical_specialty Adolescent Immunology Salivary Glands Minor Risk Assessment 03 medical and health sciences Young Adult Internal medicine medicine Humans Aged 030203 arthritis & rheumatology business.industry Lymphoma B-Cell Marginal Zone medicine.disease 030104 developmental biology business Follow-Up Studies |
| Popis: | The aim of this study is to explore the role of labial minor salivary gland (LMSG) focus score (FS) in stratifying Sjögren's Syndrome (SS) patients, lymphoma development prediction and to facilitate early lymphoma diagnosis. Ιn an integrated cohort of 1997 patients, 618 patients with FS ≥ 1 and at least one-year elapsing time interval from SS diagnosis to lymphoma diagnosis or last follow up were identified. Clinical, laboratory and serological features were recorded. A data driven logistic regression model was applied to identify independent lymphoma associated risk factors. Furthermore, a FS threshold maximizing the difference of time interval from SS until lymphoma diagnosis between high and low FS lymphoma subgroups was investigated, to develop a follow up strategy for early lymphoma diagnosis. Of the 618 patients, 560 were non-lymphoma SS patients while the other 58 had SS and lymphoma. FS, cryoglobulinemia and salivary gland enlargement (SGE) were proven to be independent lymphoma associated risk factors. Lymphoma patients with FS ≥ 4 had a statistically significant shorter time interval from SS to lymphoma diagnosis, compared to those with FS 4 (4 vs 9 years, respectively, p = 0,008). SS patients with FS ≥ 4 had more frequently B cell originated manifestations and lymphoma, while in patients with FS 4, autoimmune thyroiditis was more prevalent. In the latter group SGE was the only lymphoma independent risk factor. A second LMSG biopsy is patients with a FS ≥ 4, 4 years after SS diagnosis and in those with FS 4 and a history of SGE, at 9-years, may contribute to an early lymphoma diagnosis. Based on our results we conclude that LMSG FS, evaluated at the time of SS diagnosis, is an independent lymphoma associated risk factor and may serve as a predictive biomarker for the early diagnosis of SS-associated lymphomas. |
| Databáze: | OpenAIRE |
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