Comparative toxicity of methyl isocyanate and its hydrolytic derivatives in rats. II. Pulmonary histopathology in the subacute and chronic phases
| Autor: | Sriramachari S, Jeevaratnam K |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Pathology Time Factors Health Toxicology and Mutagenesis Injections Subcutaneous Pulmonary Fibrosis Context (language use) Pulmonary Edema Methyl isocyanate Toxicology chemistry.chemical_compound Methylamines Fibrosis Antisickling Agents Pulmonary fibrosis Administration Inhalation medicine Animals Rats Wistar Lung Methylurea Compounds Inhalation Dose-Response Relationship Drug Methylamine business.industry Hydrolysis General Medicine Lung Injury medicine.disease Rats Disease Models Animal chemistry Toxicity Histopathology business Lung Diseases Interstitial Isocyanates |
| Zdroj: | Archives of toxicology. 69(1) |
| ISSN: | 0340-5761 |
| Popis: | This paper describes the long-term (subacute and chronic) histopathological effects in the lungs of rats subjected to a single exposure to methyl isocyanate (MIC) by both the inhalation and subcutaneous (s.c.) routes as well as the role of methylamine (MA) and N,N'-dimethyl-urea (DMU), the hydrolytic derivatives of MIC in eliciting the observed changes. At the subacute phase, the intraalveolar and interstitial edema were prominent only in the inhalation group as against the more pronounced inflammatory response in the s.c. route. With the progress of time the evolution of lesions appeared to be similar, culminating in the development of significant interstitial pneumonitis and fibrosis. MA, one of the hydrolytic derivatives of MIC, also caused interstitial pneumonitis progressing to fibrosis, albeit to a lesser extent than MIC, indicating its contribution to the long-term pulmonary damage. The diffuse interstitial pulmonary fibrosis observed at 10 weeks after a single exposure to MIC by either route is of greater significance in the context of the occurrence of pulmonary fibrosis in the late autopsies of Bhopal gas victims and also clinical sequelae in some of the survivors. |
| Databáze: | OpenAIRE |
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