Evaluation of geranylgeranylacetone against cisplatin-induced ototoxicity by auditory brainstem response, heat shock proteins and oxidative levels in guinea pigs
| Autor: | Wu-Chia Lo, Po-Wen Cheng, Hillary Chiao Lee, Yi-Ho Young, Chen-Tu Wu, Yih-Leong Chang |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Guinea Pigs Oxidative phosphorylation Pharmacology Nitric Oxide Toxicology medicine.disease_cause Nitric oxide Lipid peroxidation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Ototoxicity Downregulation and upregulation Heat shock protein Evoked Potentials Auditory Brain Stem medicine Animals Hearing Disorders Heat-Shock Proteins Cisplatin Anatomy medicine.disease Cochlea Oxidative Stress 030104 developmental biology chemistry 030220 oncology & carcinogenesis Lipid Peroxidation Diterpenes Oxidative stress medicine.drug |
| Zdroj: | Neurotoxicology and Teratology. 61:29-35 |
| ISSN: | 0892-0362 |
| Popis: | This study aims to assess whether geranylgeranylacetone (GGA) could reduce ototoxicity induced by cisplatin through upregulation of not only heat shock protein(HSP)-70, but also HSP-27 and HSP-40, and to study if GGA would reduce cisplatin-induced increase in oxidative stress. 48 guinea pigs were used in this study and treated with the following regimen: 0.5% CMC (sodium carboxymethyl cellulose) control for 7days, GGA (600mg/kg/d) for 7days, a combination of GGA (600mg/kg) for 7days and then one dose of 10mg/kg cisplatin (GGA+Cis), and a combination of CMC for 7days and then 10mg/kg cisplatin (cisplatin group). Auditory brainstem response (ABR) measurement was performed in each animal at time before treatment and 7days after the last dose. Additionally, HSPs, nitric oxide (NO), and lipid peroxidation (LPO) levels in cochlear membranous tissues were assessed. The mean ABR thresholds in the cisplatin group were significantly (p |
| Databáze: | OpenAIRE |
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