Biodistribution and Metabolism of [N-methyl-11C]-m-hydroxyephedrine in the Rat

Autor:	M P, Law, S, Osman, R J, Davenport, V J, Cunningham, V W, Pike, P G, Camici
Rok vydání:	1997
Předmět:	Ephedrine Male Rats Sprague-Dawley Cancer Research Dose-Response Relationship Drug Myocardium Desipramine Animals Molecular Medicine Tissue Distribution Radiology Nuclear Medicine and imaging Carbon Radioisotopes Rats
Zdroj:	Nuclear Medicine and Biology. 24:417-424
ISSN:	0969-8051
DOI:	10.1016/s0969-8051(97)00007-3
Popis:	Biodistribution and metabolism of [N-methyl-11C]m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9ca5a524ea922451e6f74c50aaa97d https://doi.org/10.1016/s0969-8051(97)00007-3 Zobrazit plný text záznamu Full Text from ScienceDirect