Motor unit number index (MUNIX) versus motor unit number estimation (MUNE): A direct comparison in a longitudinal study of ALS patients
| Autor: | Michel J.A.M. van Putten, Helenius J. Schelhaas, Dick F. Stegeman, Machiel J. Zwarts, Johannes P. van Dijk, Werner A. Boekestein |
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| Přispěvatelé: | Kinesiology, Research Institute MOVE, Faculty of Science and Technology, Clinical Neurophysiology |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Longitudinal study DCN MP - Plasticity and memory Action Potentials Physical medicine and rehabilitation SDG 3 - Good Health and Well-being Rating scale Physiology (medical) medicine Humans Motor unit number estimation Longitudinal Studies Muscle Strength Amyotrophic lateral sclerosis Muscle Skeletal Aged Motor Neurons Amyotrophic Lateral Sclerosis Disease progression Motor unit number Middle Aged Motor neuron medicine.disease 22/4 OA procedure Sensory Systems Compound muscle action potential Human Movement & Fatigue DCN PAC - Perception action and control [NCEBP 10] medicine.anatomical_structure Neurology Nerve Degeneration Disease Progression Physical therapy Female Neurology (clinical) Psychology |
| Zdroj: | Boekestein, W A, Schelhaas, H J, van Putten, M J, Stegeman, D F, Zwarts, M J & Dijk, J P 2012, ' Motor unit number index (MUNIX) versus motor unit number estimation (MUNE): A direct comparison in a longitudinal study of ALS patients ', Clinical Neurophysiology, vol. 123, no. 8, pp. 1644-1649 . https://doi.org/10.1016/j.clinph.2012.01.004 Clinical Neurophysiology, 123, 8, pp. 1644-9 Clinical Neurophysiology, 123, 1644-9 Clinical Neurophysiology, 123(8), 1644-1649. International Federation of Clinical Neurophysiology Clinical neurophysiology, 123(8), 1644-1649. Elsevier |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2012.01.004 |
| Popis: | highlights � This study shows that the motor unit number index (MUNIX) and high-density motor unit number esti- mation (MUNE) outcomes measured on the thenar muscle are significantly correlated in ALS patients. � After 8 months follow-up, MUNIX and high-density MUNE values in ALS patients showed significantly more decline compared to CMAP, ALS functional rating scale and MRC-scale. � There was no significant difference in relative decline between MUNIX and high-density MUNE values, showing their equivalent potential in detecting motor neuron loss. abstract Objective: To evaluate how the motor unit number index (MUNIX) is related to high-density motor unit number estimation (HD-MUNE) in healthy controls and patients with amyotrophic lateral sclerosis (ALS). Methods: Both MUNIX and HD-MUNE were performed on the thenar muscles in 18 ALS patients and 24 healthy controls. Patients were measured at baseline, within 2 weeks, and after 4 and 8 months. Clinical evaluation included Medical Research Council (MRC) scale and the ALS functional rating scale (ALSFRS). Results: There was a significant positive correlation between MUNE and MUNIX values in ALS patients (r = 0.49 at baseline; r = 0.56 at 4 months; r = 0.56 at 8 months, all p < 0.05), but not in healthy controls. After 8 months, both MUNE and MUNIX values of the ALS patients decreased significantly more com- pared to MRC scale, ALS functional rating scale (ALSFRS) and compound muscle action potential (CMAP) (p < 0.05). There was no significant difference in relative decline of MUNIX and HD-MUNE values. Conclusions: In ALS patients, MUNIX and HD-MUNE are significantly correlated. MUNIX has an almost equivalent potential in detecting motor neuron loss compared to HD-MUNE. Significance: MUNIX could serve as a reliable and sensitive marker for monitoring disease progression in ALS. |
| Databáze: | OpenAIRE |
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