Effects of Whole-Grain and Sugar Content in Infant Cereals on Gut Microbiota at Weaning: A Randomized Trial
| Autor: | Salvador Genovés, Julio Plaza-Díaz, Sophie Schutte, Luis Manuel Sanchez-Siles, Maria Jose Bernal, Francisco M. Codoñer, Empar Chenoll, Angel Gil |
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| Přispěvatelé: | [Plaza-Diaz,J, Gil,A] Department of Biochemistry & Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Plaza-Diaz,J, Gil,A] Instituto de Investigación Biosanitaria IBS. GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Plaza-Diaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Bernal,MJ, Schutte,S, Sanchez-Siles,LM] Research and Nutrition Department, Hero Group, Alcantarilla, Murcia, Spain. [Bernal,MJ, Sanchez-Siles,LM] Institute for Research and Nutrition, Hero Group, Lenzburg, Switzerland. [Chenoll,E, Genovés,S, Codoñer,FM] Biopolis-ADM, Paterna, Spain. [Gil,A] Institute of Nutrition & Food Technology 'José Mataix', Biomedical Research Center, University of Granada, Granada, Spain. [Gil,A] CIBEROBN (CIBER Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain., This research was partially funded by European funding from ICEX and FEDER—Program R + D Invest 539 in Spain 2015. European Regional Development Fund: 201503473. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male intestinal microbiota Intestinal microbiota Dietary Sugars Grano comestible Ensayo clínico controlado aleatorio Gut flora Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] TX341-641 Food science Persons::Persons::Age Groups::Infant [Medical Subject Headings] Nutrition and Dietetics biology Microbiota food and beverages Infant food Whole grains whole grains Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Weaning [Medical Subject Headings] Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] Chemicals and Drugs::Carbohydrates::Sugar Phosphates [Medical Subject Headings] Female Proteobacteria Fenómenos fisiológicos nutricionales del lactante Microbioma gastrointestinal Publication Type::Study Characteristics::Clinical Trial::Randomized Controlled Trial [Medical Subject Headings] Check Tags::Male [Medical Subject Headings] Complementary feeding Weaning Article complementary feeding 03 medical and health sciences Technology and Food and Beverages::Food and Beverages::Food::Foods Specialized::Infant Food [Medical Subject Headings] infant food Escherichia infant cereals Humans Sugar Feces Cereales integrales Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings] 030109 nutrition & dietetics Nutrition. Foods and food supply Infant biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Enterococcus Alimentos para lactantes Check Tags::Female [Medical Subject Headings] Spain Destete Infant cereals Bacteroides Food Science |
| Zdroj: | Nutrients Volume 13 Issue 5 Nutrients, Vol 13, Iss 1496, p 1496 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13051496 |
| Popis: | The introduction of complementary foods during infancy marks an important step in the development of the infant gut microbiome. Infant cereals are popular weaning foods but consistent evidence on their effect on the intestinal microbiota, especially when differing in nutritional quality, is lacking. Fecal samples from 4–7-month-old Spanish infants who consumed infant cereals differing in whole grain and sugar content as first weaning foods were analyzed on changes in microbial composition by massively parallel sequencing of the 16S ribosomal RNA gene at baseline and after 7 weeks of intervention. Samples were obtained from a previous trial conducted in Spain demonstrating whole-grain cereal acceptability. In total, samples of 18 infants consuming 0% whole grain cereals with 24 g sugar (0-WG) and 25 infants consuming 50% whole grain cereals with 12 g sugar (50-WG) were analyzed. Microbial composition changed significantly over time (p = 0.001), per intervention group (p = 0.029) and per infant (p = 0.001). Abundance of genus Veillonella increased in both groups while Enterococcus decreased. Within the 0-WG group, phylum Actinobacteria decreased along with genus Bifidobacterium. In the 50-WG, we observed an increase in Lachnoclostridium and Bacteroides. In addition, 50-WG decreased Proteobacteria and Escherichia to levels lower than 0-WG. Although weaning itself appeared to be responsible for most changes, the increased presence of anaerobic fermenters together with inhibition of pathogenic Escherichia may indicate a supporting effect of infant cereals with 50% whole grains and a reduced sugar content over infant cereals manufactured with refined hydrolyzed flours on the infant microbiota. In fact, using a novel methodology for the identification of microbial signatures, we found two groups of microbial taxa predictive of infants consuming enriched whole-grain infant cereals with a high predictive value of about 93%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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