The way forward for assessing the human health safety of cosmetics in the EU workshop proceedings

Autor: Petra S. Kern, Kirstin Kosemund-Meynen, Maciej Stępnik, Christophe Rousselle, Natalie von Goetz, Janine Ezendam, Gladys Ouedraogo, Ulrike Bernauer, Emilio Benfenati, Mark T. D. Cronin, Carsten Goebel, Qasim Chaudhry, Paul L. Carmichael, Eric Gaffet, Pieter Jan Coenraads, Heli M. Hollnagel, Laurent Bodin, Berit Granum, Corrado L. Galli, Andrew Worth, Vera Rogiers, Matthew P. Dent, Maria Dusinska, Tamara Vanhaecke, Eirini Panteri, Corie A. Ellison
Přispěvatelé: Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Experimental in vitro toxicology and dermato-cosmetology, Vriendenkring VUB, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Scientific Committee for Consumer Safety (European Commission) (SCCS), Scientific Committee for Consumer Safety (SCCS) (SCCS), Vrije Universiteit Brussel (VUB), Mario Negri Institute- IRCCS, Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unilever-Safety & Environmental Assurance Centre, Unilever, University of Chester, University Medical Center Groningen [Groningen] (UMCG), Liverpool John Moores University (LJMU), Norsk Institutt for Luftforskning (NILU), Procter & Gamble (P&G), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Milan, Norwegian Institute of Public Health [Oslo] (NIPH), Dow Europe GmbH, L'Oréal Recherche France (L'Oréal Recherche), L'OREAL, National and Kapodistrian University of Athens (NKUA), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Nofer Institute of Occupational Medicine (NIOM), Swiss Federal Office of Public Health, European Commission - Joint Research Centre [Ispra] (JRC), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano = University of Milan (UNIMI)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
READ-ACROSS
Next generation risk assessment
media_common.quotation_subject
MESH: Consumer Product Safety
Context (language use)
UNCERTAINTY
SUBSTANCES
Cosmetics
Hazard analysis
Toxicology
RS
THRESHOLD
03 medical and health sciences
Human health
0302 clinical medicine
TOXICOLOGICAL CONCERN VALUES
Product (category theory)
EXPOSURE
Animal testing alternatives
ComputingMilieux_MISCELLANEOUS
media_common
Alternative methods
RISK
CONCERN TTC
IDENTIFICATION
Animal-Free method
Replacement method
MESH: Cosmetics
DEVELOPMENTAL TOXICITY
030104 developmental biology
Risk analysis (engineering)
New approach methodology
Safety assessment
Animal Testing Alternative
Alternative method
Cosmetic Products
[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]
Risk assessement
Business
Risk assessment
030217 neurology & neurosurgery
Zdroj: Toxicology
Toxicology, Elsevier, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
Toxicology, 2020, 436, pp.152421. ⟨10.1016/j.tox.2020.152421⟩
ISSN: 0300-483X
DOI: 10.1016/j.tox.2020.152421
Popis: International audience; Although the need for non-animal alternatives has been well recognised for the human health hazard assessment of chemicals in general, it has become especially pressing for cosmetic ingredients due to the full implementation of testing and marketing bans on animal testing under the European Cosmetics Regulation. This means that for the safety assessment of cosmetics, the necessary safety data for both the ingredients and the finished product can be drawn from validated (or scientifically-valid), so-called "Replacement methods". In view of the challenges for safety assessment without recourse to animal test data, the Methodology Working Group of the Scientific Committee on Consumer Safety organised a workshop in February 2019 to discuss the key issues in regard to the use of animal-free alternative methods for the safety evaluation of cosmetic ingredients. This perspective article summarises the outcomes of this workshop and reflects on the state-of-the-art and possible way forward for the safety assessment of cosmetic ingredients for which no experimental animal data exist. The use and optimisation of "New Approach Methodology" that could be useful tools in the context of the "Next Generation Risk Assessment" and the strategic framework for safety assessment of cosmetics were discussed in depth.
Databáze: OpenAIRE
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