Bone Turnover in Homozygous ß2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates
| Autor: | Ana Marušić, Vedran Katavić, Dinko Štimac, Vesna Kusec, Stipan Jonjić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Male
Heterozygote medicine.medical_specialty Clinical Biochemistry education Major histocompatibility complex Bone and Bones Bone remodeling Mice Immune system Osteoclast Internal medicine medicine Animals Bone Resorption Mice Knockout Bone Development biology Beta-2 microglobulin Homozygote Biochemistry (medical) BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences General Medicine Mice Inbred C57BL Apposition medicine.anatomical_structure Endocrinology Knockout mouse biology.protein Alkaline phosphatase Female beta 2-Microglobulin BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti |
| Zdroj: | European journal of clinical chemistry and clinical biochemistry Volume 33 Europe PubMed Central |
| ISSN: | 0939-4974 |
| Popis: | beta 2-Microglobulin is a constituent of the class I major histocompatibility complex (MHC) molecule and crucial for its normal function in cell recognition. It has also been isolated from bone and shown to regulate bone metabolism and to be altered in various bone diseases. In order to further investigate the role of the immune system in bone metabolism, we studied basic properties of bone physiology in beta 2-microglobulin-deficient mice created by the technique of gene knock-out. Ten week-old male offspring homozygous (non-functional class I MHC molecule) or heterozygous (functional class I MHC molecule) for beta 2-microglobulin knock-out gene did not differ in the following measures of bone turnover: femur length, dry and ash weight and calcium content, serum calcium concentration and alkaline phosphatase activity, total vertebral tissue area, trabecular bone volume, osteid surface, osteoclast surface and mineral apposition rate. These data indicate that the bone turnover in beta 2-microglobulin-deficient mice is appropriate for the stage of their skeletal maturation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|