Melanin-concentrating hormone and its receptor are expressed and functional in human skin
| Autor: | Itaru Suzuki, Siân E. Estdale, Janis Ancans, Anthony J. Thody, Martin J. Hoogduijn |
|---|---|
| Přispěvatelé: | Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Transcription Genetic Melanin-concentrating hormone Biophysics Human skin Melanocyte Biology Biochemistry chemistry.chemical_compound Internal medicine Cyclic AMP Tumor Cells Cultured medicine Humans RNA Messenger Receptors Pituitary Hormone Receptor Molecular Biology Cells Cultured Skin Melanocortins Melanins Hypothalamic Hormones Dose-Response Relationship Drug integumentary system Melanoma Cell Biology respiratory system medicine.disease Cell biology Pituitary Hormones Endocrinology medicine.anatomical_structure chemistry alpha-MSH Hormone receptor Melanocytes hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Biochemical and Biophysical Research Communications, 296(3), 698-701. Academic Press |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(02)00932-4 |
| Popis: | In this study, we have demonstrated the presence of melanin-concentrating hormone (MCH) and melanin-concentrating hormone receptor (MCHR1) transcripts in human skin. Sequence analysis confirmed that the transcripts of both genes were identical to those previously found in human brain. In culture, endothelial cells showed pro-MCH expression whereas no signal was found in keratinocytes, melanocytes, and fibroblasts. MCHR1 expression was restricted to melanocytes and melanoma cells. Stimulation of cultured human melanocytes with MCH reduced the alpha-MSH-induced increase in cAMP production. Furthermore, the melanogenic actions of alpha-MSH were inhibited by MCH. We propose that the MCH/MCHR1 signalling system is present in human skin and may have a role with the melanocortins in regulating the melanocyte. |
| Databáze: | OpenAIRE |
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