Syndecan-1 and free indoxyl sulfate levels are associated with miR-126 in chronic kidney disease
| Autor: | Fourdinier, O., Glorieux, Griet, Birgant, B, Dioef, M, Pletinck, Anneleen, Vanholder, Raymond, Choukroun, G, Verbeke, Francis, Mazzy, Z.A, Metzinger-Le Meuth, V, Metzinger, L, Group, E.O |
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| Přispěvatelé: | Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, Ghent University Hospital, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, metzinger, laurent, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Hôpital Ambroise Paré [AP-HP], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, This research study was funded by SFNDT and Vifor (L.M., V.M.-L.M., B.B. and G.C.) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
MICRORNAS uremic toxins Disease 030204 cardiovascular system & hematology [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology Gastroenterology endothelium dysfunction Syndecan 1 Cohort Studies 0302 clinical medicine Medicine and Health Sciences Biology (General) Endothelial dysfunction Spectroscopy Cause of death DAMAGE 0303 health sciences Univariate analysis microRNA General Medicine Middle Aged miR-126 Pathophysiology 3. Good health Computer Science Applications Chemistry [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Biomarker (medicine) biomarker Female Glomerular Filtration Rate Adult medicine.medical_specialty QH301-705.5 P-CRESYL SULFATE Glycocalyx Catalysis Article Inorganic Chemistry 03 medical and health sciences [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Internal medicine medicine Humans Physical and Theoretical Chemistry Renal Insufficiency Chronic indoxyl sulfate QD1-999 Molecular Biology 030304 developmental biology Aged Toxins Biological Uremia business.industry Organic Chemistry syndecan-1 medicine.disease [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology MicroRNAs Multivariate Analysis Linear Models business Indican Biomarkers chronic kidney disease Kidney disease |
| Zdroj: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2021, 22 (19), pp.10549. ⟨10.3390/ijms221910549⟩ International Journal of Molecular Sciences, Vol 22, Iss 10549, p 10549 (2021) International Journal of Molecular Sciences, 2021, 22 (19), pp.10549. ⟨10.3390/ijms221910549⟩ Volume 22 Issue 19 |
| ISSN: | 1422-0067 1661-6596 |
| DOI: | 10.3390/ijms221910549⟩ |
| Popis: | International audience; Chronic kidney disease (CKD) is a major cause of death worldwide and is associated with a high risk for cardiovascular and all-cause mortality. In CKD, endothelial dysfunction occurs and uremic toxins accumulate in the blood. miR-126 is a regulator of endothelial dysfunction and its blood level is decreased in CKD patients. In order to obtain a better understanding of the physiopathology of the disease, we correlated the levels of miR-126 with several markers of endothelial dysfunction, as well as the representative uremic toxins, in a large cohort of CKD patients at all stages of the disease. Using a univariate analysis, we found a correlation between eGFR and most markers of endothelial dysfunction markers evaluated in this study. An association of miR-126 with all the evaluated uremic toxins was also found, while uremic toxins were not associated with the internal control, specifically cel-miR-39. The correlation between the expression of endothelial dysfunction biomarker Syndecan-1, free indoxyl sulfate, and total p-cresyl glucuronide on one side, and miR-126 on the other side was confirmed using multivariate analysis. As CKD is associated with reduced endothelial glycocalyx (eGC), our results justify further evaluation of the role of correlated parameters in the pathophysiology of CKD. |
| Databáze: | OpenAIRE |
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