GRF treatment of late pregnant ewes alters maternal and fetal somatotropic axis activity
| Autor: | G. Kann, R. Garcia-Villar, C. G. Goodyer, B. Barenton, Pierre-Louis Toutain, J. Charrier, Monique Blanchard, Alain Bousquet-Mélou |
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| Přispěvatelé: | Bousquet-Mélou, Alain, Physiologie et Toxicologie Expérimentales, Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées |
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Physiology
Endocrinology Diabetes and Metabolism MESH: Somatostatin MESH: Insulin-Like Growth Factor I Growth Hormone-Releasing Hormone MESH: Insulin-Like Growth Factor II 0302 clinical medicine MESH: Pregnancy Pregnancy Reference Values MESH: Gestational Age MESH: Growth Hormone-Releasing Hormone MESH: Animals Placental lactogen Insulin-Like Growth Factor I 0303 health sciences MESH: Reference Values MESH: Pregnancy Animal Fetal Blood Somatomedin 3. Good health GH Somatostatin [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Gestation Female medicine.medical_specialty INSULINE LIKE GROWTH FACTOR Somatotropic cell MESH: Sheep 030209 endocrinology & metabolism Gestational Age Biology IGFII 03 medical and health sciences Fetus Insulin-Like Growth Factor II Physiology (medical) Internal medicine medicine Endocrine system Animals MESH: Fetal Blood IGFI 030304 developmental biology Sheep MESH: Fetus medicine.disease Endocrinology Growth Hormone MESH: Growth Hormone [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Pregnancy Animal STH MESH: Female |
| Zdroj: | American Journal of Physiology American Journal of Physiology, American Physiological Society, 1991, 260 (4 Pt 1), pp.E575-80 Scopus-Elsevier |
| ISSN: | 0002-9513 |
| Popis: | International audience; To examine the effects of anabolic agents given during late gestation on the maternal and fetal somatotropic axes, we injected pregnant ewes twice daily with 0.15 mg somatocrinin (GRF)-(1-29) for 10 days beginning on day 130 of gestation. Maternal and fetal endocrine changes were compared with control animals using both in vivo and in vitro approaches. Treatment with GRF increased maternal plasma levels of growth hormone (GH) and insulin-like growth factor I (IGF-I;P less than 0.05) but not IGF-II. Under in vitro test conditions, maternal pituitary cells showed a greater maximal response (P less than 0.001) to GRF. In the fetuses of treated ewes, cord plasma GH levels were not significantly increased compared with controls. These animals had similar IGF-I but higher IGF-II (P less than 0.05) plasma levels. The maximal response of fetal pituitary cells to GRF was increased (P less than 0.001). GRF treatment had no influence on maternal and fetal pituitary cell responses to somatostatin under either basal or GRF-stimulated conditions. In addition, these treatments did not affect plasma levels of placental lactogen, glucose, or free fatty acids in the maternal and fetal sheep. These data are compatible with the hypothesis that treatment of pregnant ewes in the last days of gestation with GRF could support accelerated fetal growth. |
| Databáze: | OpenAIRE |
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