Mycoplasma pneumoniae infection in primary care investigated by real-time PCR in England and Wales
| Autor: | C. Sadler, Douglas M. Fleming, Joanna Ellis, M. Mentasti, Timothy G. Harrison, Alison Bermingham, Victoria J. Chalker, T. Stocki |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Microbiology (medical) myalgia medicine.medical_specialty Mycoplasma pneumoniae Adolescent Mycoplasmataceae Nose medicine.disease_cause Polymerase Chain Reaction Young Adult Age Distribution Medical microbiology Throat Internal medicine Epidemiology medicine Humans Mycoplasma Infections Child Respiratory Tract Infections Aged Aged 80 and over Bacteriological Techniques Wales Primary Health Care biology Infant Newborn Infant General Medicine Middle Aged biology.organism_classification Virology Infectious Diseases medicine.anatomical_structure England Molecular Diagnostic Techniques Child Preschool Mollicutes Pharynx Female medicine.symptom |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 30:915-921 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-011-1176-3 |
| Popis: | Real-time PCR was employed to detect a conserved region of the P1 cytadhesin gene of Mycoplasma pneumoniae in combined nose and throat swabs collected from patients attending GP surgeries during 2005-2009 with symptoms of respiratory tract infection (RTI). Samples were collected as part of an annual winter epidemiological and virological linked study in England and Wales. A total of 3,987 samples were tested, 65 (1.7%, 95%CI 1.3-2.1) had detectable M. pneumoniae DNA. Positive patients were detected of both gender, aged from 9 months to 78 years, who had clinical signs of upper RTI, fever and/or myalgia, an influenza-like illness to lower RTI. Mixed infections were identified in four cases, two with influenza A H1, one with H3 and one with influenza B. Children aged 5-14 years were more likely to have detectable M. pneumoniae in samples than all other age groups (Fishers p = 0.03), attributed to the 2005-2006 season in which 6.0% (12/200, 95%CI 3.4-10.3) of 5-14 year olds had detectable M. pneumoniae in comparison to 2.2% in 2006-2007 (3/141 95%CI 0.5-6.4), 2.2% in 2007-2008 (2/89 95%CI 0.1-8.3) and 0% in 2008-2009 (0/151 95%CI 0-2.9). |
| Databáze: | OpenAIRE |
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