Unstimulated whole salivary flow in Sjögren’s Syndrome: systematic literature review and meta-analysis
| Autor: | Jairo Cajamarca-Baron, Natalia Aguilera, Adriana Rojas-Villarraga, Juan Pablo Alzate-Granados, Kenny Carolina Garzón-González, María Alejandra Martínez-Ceballos |
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| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Autoimmune diseases Autoimmunity Salivary glands Xerostomia law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology Randomized controlled trial law Internal medicine Sicca syndrome medicine Humans Saliva Prospective cohort study 030203 arthritis & rheumatology business.industry Retrospective cohort study 030206 dentistry Publication bias Sjogren's Syndrome Systematic review Sjögren’s syndrome Meta-analysis Sjögren's syndrome lcsh:RC925-935 lcsh:RC581-607 Salivation business Cohort study |
| Zdroj: | Advances in Rheumatology, Vol 61, Iss 1, Pp 1-12 (2021) Advances in Rheumatology, Volume: 61, Article number: 8, Published: 12 FEB 2021 |
| ISSN: | 2523-3106 |
| DOI: | 10.1186/s42358-020-00158-0 |
| Popis: | Background Sjögren’s Syndrome compromises the exocrine function, producing xerostomia and xerophthalmia. It can appear as an isolated condition or associated with other autoimmune diseases (polyautoimmunity). The Unstimulated Salivary Flow rate (UWSF) is used to quantify saliva production. There is no objective evidence to differentiate the values in patients with Sjögren’s versus healthy people or patients with non-Sjögren’s sicca. The objective of the present review was to evaluate the UWSF in patients with Sjögren’s syndrome in comparison to controls (healthy and non-Sjögren’s sicca patients). Methods A systematic literature review was carried out (PRISMA guidelines). Analytical observational studies of cases and controls, cross-sectional studies, cohort studies and randomized clinical trials (including healthy controls) were considered. The Medline/OVID, Lilacs, Embase, and Cochrane/OVID databases were consulted. MeSH, DeCS, keywords, and Boolean operators were used. The meta-analysis (RevMan 5.2) was done through the random-effects model [mean difference (MD)]. Level and quality of evidence were evaluated by the Oxford Center Levels of Evidence and Joanna Brigs list respectively. Results Thirty-two articles were included (20 were case-control studies, 6 were cross-sectional, 2 prospective cohort, 2 retrospective cohort, and 2 studies were abstracts) and 28 were meta-analyzed. The unstimulated whole salivary flow rate in the Sjögren’s group was lower than in controls (healthy and patients with non-Sjögren Sicca syndrome) (MD-0.18 ml/min; 95% CI, − 0.24 to − 0.13; chi2-P-value Conclusion For the first time, the unstimulated whole salivary flow rate is found to be lower in patients with Sjögren’s syndrome compared to controls (healthy and non-SS sicca) through a meta-analysis. Trial registration PROSPERO CRD42020211325. |
| Databáze: | OpenAIRE |
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