Cannabis and tolerance
Autor: | J.H.P. van Wel, Johannes G. Ramaekers, Desirée Spronk, Stefan W. Toennes, Eef L. Theunissen, Robbert-J. Verkes, Kim P. C. Kuypers |
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Přispěvatelé: | RS: FPN NPPP II, Section Psychopharmacology |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Drug
PSYCHOMOTOR PERFORMANCE medicine.medical_specialty media_common.quotation_subject Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Poison control FREQUENT MOTOR CONTROL Placebo SMOKED MARIJUANA 03 medical and health sciences ORAL DELTA(9)-TETRAHYDROCANNABINOL 0302 clinical medicine Drug tolerance MARIHUANA Medicine Psychiatry media_common Psychomotor function Multidisciplinary biology business.industry biology.organism_classification 030227 psychiatry Cannabis Dronabinol HEAVY business THC INTOXICATION COCAINE Neurocognitive 030217 neurology & neurosurgery RESPONSES |
Zdroj: | Scientific Reports, 6 Scientific Reports, 6:26843. Nature Publishing Group |
ISSN: | 2045-2322 |
DOI: | 10.1038/srep26843 |
Popis: | Contains fulltext : 167132.pdf (Publisher’s version ) (Open Access) Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The present study assessed the influence of cannabis on neurocognition in cannabis users whose cannabis use history ranged from infrequent to daily use. Drug users (N = 122) received acute doses of cannabis (300 mug/kg THC), cocaine HCl (300 mg) and placebo. Cocaine served as active control for demonstrating neurocognitive test sensitivity. Executive function, impulse control, attention, psychomotor function and subjective intoxication were significantly worse after cannabis administration relative to placebo. Cocaine improved psychomotor function and attention, impaired impulse control and increased feelings of intoxication. Acute effects of cannabis and cocaine on neurocognitive performance were similar across cannabis users irrespective of their cannabis use history. Absence of tolerance implies that that frequent cannabis use and intoxication can be expected to interfere with neurocognitive performance in many daily environments such as school, work or traffic. |
Databáze: | OpenAIRE |
Externí odkaz: |
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