Planning-free cerebral blood flow territory mapping in patients with intracranial arterial stenosis
| Autor: | Megan K. Strother, Daniel F Arteaga, L. Taylor Davis, Matthew R. Fusco, Allison O. Scott, Brent A Roach, Manus J. Donahue, Carlos C Faraco |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Arterial Spin Labeling MRI Internal medicine medicine.artery Humans Medicine In patient Neuroradiology medicine.diagnostic_test business.industry Arterial stenosis Original Articles Cerebral Arteries Middle Aged Intracranial Arteriosclerosis Cerebral Angiography Neurology Cerebral blood flow Case-Control Studies Cerebrovascular Circulation Arterial spin labeling Angiography Cardiology Circle of Willis Female Neurology (clinical) Radiology Cardiology and Cardiovascular Medicine business Magnetic Resonance Angiography 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 37:1944-1958 |
| ISSN: | 1559-7016 0271-678X |
| DOI: | 10.1177/0271678x16657573 |
| Popis: | A noninvasive method for quantifying cerebral blood flow and simultaneously visualizing cerebral blood flow territories is vessel-encoded pseudocontinuous arterial spin labeling MRI. However, obstacles to acquiring such information include limited access to the methodology in clinical centers and limited work on how clinically acquired vessel-encoded pseudocontinuous arterial spin labeling data correlate with gold-standard methods. The purpose of this work is to develop and validate a semiautomated pipeline for the online quantification of cerebral blood flow maps and cerebral blood flow territories from planning-free vessel-encoded pseudocontinuous arterial spin labeling MRI with gold-standard digital subtraction angiography. Healthy controls (n = 10) and intracranial atherosclerotic disease patients (n = 34) underwent 3.0 T MRI imaging including vascular (MR angiography) and hemodynamic (cerebral blood flow-weighted arterial spin labeling) MRI. Patients additionally underwent catheter and/or CT angiography. Variations in cross-territorial filling were grouped according to diameters of circle of Willis vessels in controls. In patients, Cohen’s k-statistics were computed to quantify agreement in perfusion patterns between vessel-encoded pseudocontinuous arterial spin labeling and angiography. Cross-territorial filling patterns were consistent with circle of Willis anatomy. The intraobserver Cohen's k-statistics for cerebral blood flow territory and digital subtraction angiography perfusion agreement were 0.730 (95% CI = 0.593–0.867; reader one) and 0.708 (95% CI = 0.561–0.855; reader two). These results support the feasibility of a semiautomated pipeline for evaluating major neurovascular cerebral blood flow territories in patients with intracranial atherosclerotic disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|