Early weaning disrupts feeding patterns in female juvenile rats through 5HT-system modulations
| Autor: | Julliet Araújo de Souza, Larissa Cavalcanti do Amaral Almeida, Matilde Cesiana da Silva, Gabriel Araújo Tavares, Sandra Lopes de Souza, Elizabeth do Nascimento, Glauber Rudá Feitosa Braz, Claudia Jacques Lagranha |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Serotonin Period (gene) Hypothalamus Physiology Weaning Biology Serotonergic 010603 evolutionary biology 01 natural sciences Eating Behavioral Neuroscience Animals Juvenile 0501 psychology and cognitive sciences RNA Messenger 050102 behavioral science & comparative psychology Circadian rhythm Rats Wistar Maternal Behavior Body Weight 05 social sciences Brain RNA-Binding Proteins Feeding Behavior Organ Size General Medicine Circadian Rhythm Rats Female Animal Science and Zoology Brainstem Energy Intake Brain Stem |
| Zdroj: | Behavioural Processes. 170:103981 |
| ISSN: | 0376-6357 |
| DOI: | 10.1016/j.beproc.2019.103981 |
| Popis: | Convergent evidence in literature shows that rapid disruption of maternal care and breastfeeding due to an early weaning protocol changes the development of several neurobehavioral patterns in rodents, including the circadian pattern of feeding. The serotoninergic system has been associated with the control of feeding patterns. Therefore, we aim to evaluate the patterns of feeding, the mRNA expression of 5 H T-1b, 5 H T-2c, and SERT on the hypothalamus, brainstem, and the body weight of female juvenile Wistar rats, submitted to early (PND15) or regular (PND30) weaning. The results demonstrate that early weaning promotes an increase in food intake in a 24 -h period, in the dark phase of the circadian cycle and in the four-hour time intervals at the beginning of the dark and light phases. Also, early weaning decreases the mRNA expression of 5 H T-1b, 5 H T-2c, and SERT on the hypothalamus, but increases it on the brainstem. Additionally, early weaning promotes an increase in body weight. Therefore, the present data demonstrate that early weaning changes the patterns of feeding in juvenile female rats and suggests that this behavioral modification is due to the modulations promoted in the 5 H T-system. |
| Databáze: | OpenAIRE |
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