Determinant factors for adherence to antiretroviral therapy among adult HIV patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia: a case–control study
| Autor: | Betelhem Walelgn, Mehd Abdu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Tuberculosis Referral 030106 microbiology HIV Infections Disease Dessie Referral Hospital Medication Adherence 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Virology Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Referral and Consultation business.industry Research Case-control study Infant Newborn RC581-607 medicine.disease Antiretroviral therapy Hospitals Cross-Sectional Studies Adherence Concomitant Case-Control Studies Respondent Molecular Medicine HIV/AIDS Female Ethiopia Immunologic diseases. Allergy business |
| Zdroj: | AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-9 (2021) AIDS Research and Therapy |
| ISSN: | 1742-6405 |
| Popis: | Introduction World health organization defined adherence as the extent to which a person’s behavior – taking medications, following a diet, or executing lifestyle changes correspond with agreed recommendations from the health care provider. There is a contradiction among studies and previous studies conducted in the study area used a cross-sectional study design. This study aimed to identify determinant factors for adherence to antiretroviral treatment among people living with HIV at Dessie Referral Hospital by using an unmatched case–control study design. Methods and materials an institution-based unmatched case–control study design was used on a total sample of 582 (146 controls and 436 cases). Each respondent was selected by consecutive random sampling. The collected data were entered and analyzed by using Statistical Package for Social Science version 25.0. Multivariable binary logistic regression analysis was used to identify variables that were statistically significant determinants. Result The mean age of the respondents was 41.64 years. About 61.5% of the participants were females. Patients with baseline HIV stage I was more likely to be adherent to the prescribed HIV medicine (AOR: 2.194 95% CI: 1.116, 4.314) as compared with those with baseline WHO stage IV. Patients who did not take anti-tuberculosis medication collaterally with the prescribed HIV medicine were more likely to be adherent (AOR: 2.271 95% CI: 1.257, 4.102). Patients who took antiretroviral therapy for more than 24 months were more likely to be adherent (AOR: 3.665 95% CI: 1.321, 10.170). Conclusion Initiation of antiretroviral therapy at the later stage of the disease and taking anti-tuberculosis concomitantly were negatively associated with adherence. Being on antiretroviral therapy for a longer duration has a positive association. Health facilities and professionals should strictly apply strategies for the prevention of tuberculosis among HIV patients to avoid concomitant use of anti-tuberculosis medications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|