Laryngeal cancer and occupational exposure to sulfuric acid
| Autor: | N Herrmann, J S Mausner, N M Hanis, Colin L. Soskolne, L L Kupper, J Amsel, Jeanne Mager Stellman, E A Zeighami |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Alcohol Drinking Epidemiology Occupational disease Physiology Medical Records medicine Humans Laryngeal Neoplasms Carcinogen Retrospective Studies business.industry Smoking Absolute risk reduction Cancer Retrospective cohort study Sulfuric Acids medicine.disease Louisiana Respiratory Tract Neoplasms Surgery Occupational Diseases Relative risk Risk assessment business Epidemiologic Methods |
| Zdroj: | American journal of epidemiology. 120(3) |
| ISSN: | 0002-9262 |
| Popis: | Workers on an ethanol unit which used sulfuric acid in strong concentrations at a large refinery and chemical plant in Baton Rouge, Louisiana were reported, in 1979, at excess risk for upper respiratory cancer. The carcinogen implicated by indirect evidence was diethyl sulfate. However, with the continued use of sulfuric acid in the same plant, and with additional cases not attributable to the ethanol process, the hypothesis of an association between sulfuric acid exposure and upper respiratory cancer was tested. Each of 50 confirmed cases of upper respiratory cancer diagnosed between 1944 and 1980, was matched to at least three controls on sex, race, age, date of initial employment, and duration of employment. Thirty-four of the 50 cases were laryngeal cancers. Data were obtained from existing plant records. Retrospective estimates of exposure were made without regard to case or control status. Findings from conditional logistic regression techniques were supported by other statistical methods. Among workers classified as potentially highly exposed, four-fold relative risks for all upper respiratory cancer sites combined were exceeded by the relative risk for laryngeal cancer specifically. Exposure-response and consistency across various comparisons after controlling statistically for tobacco-use, alcoholism and other previously implicated risk factors, suggest increased cancer risk with higher exposure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|