Mismatch repair protein status (MLH1, MSH2, MSH6) in paired initial and recurrent glioblastoma

Autor:	Stark, A, Doukas, A, Hugo, HH, Mehdorn, HM
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	congenital hereditary and neonatal diseases and abnormalities ddc: 610 nutritional and metabolic diseases 610 Medical sciences Medicine complex mixtures neoplasms digestive system diseases
Zdroj:	60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien; 20090524-20090527; Münster; DOCP04-01 /20090520/
DOI:	10.3205/09dgnc281
Popis:	Objective: There is evidence that defective DNA mismatch repair (MMR) results in tolerance to temozolomide regardless of O(6)-alkylguanine-DNA alkyltransferase (AGT) activity. Dysfunction of MMR genes, in particular MLH1, MSH2, and MSH6, leads to loss of MMR protein expression and to microsatellite [for full text, please go to the a.m. URL] 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien
Databáze:	OpenAIRE
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