Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentary time and vigorous activity
| Autor: | Jerzy Adamski, Sven Knüppel, Dagmar Drogan, Anna Floegel, Matthaeus Vigl, Heiner Boeing, Tobias Pischon, Angelika Wientzek |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Metabolite Movement Population Physical fitness Physical Exertion Medicine (miscellaneous) Type 2 diabetes chemistry.chemical_compound Methionine Heart Rate Risk Factors Tandem Mass Spectrometry Diabetes mellitus Internal medicine Heart rate Medicine Humans Orthopedics and Sports Medicine Risk factor education Exercise education.field_of_study Nutrition and Dietetics business.industry Lysophosphatidylcholines Cardiorespiratory fitness General Medicine Middle Aged medicine.disease Endocrinology chemistry Diabetes Mellitus Type 2 Physical Fitness Exercise Test Female Sedentary Behavior business Energy Metabolism |
| Zdroj: | International journal of sport nutrition and exercise metabolism. 24(2) |
| ISSN: | 1543-2742 |
| Popis: | The aim of our study was to investigate the relationship between objectively measured physical activity (PA) and cardiorespiratory fitness (CRF) and serum metabolites measured by targeted metabolomics in a population- based study. A total of 100 subjects provided 2 fasting blood samples and engaged in a CRF and PA measurement at 2 visits 4 months apart. CRF was estimated from a step test, whereas physical activity energy expenditure (PAEE), time spent sedentary and time spend in vigorous activity were measured by a combined heart rate and movement sensor for a total of 8 days. Serum metabolite concentrations were determined by flow injection analysis tandem mass spectrometry (FIA-MS/MS). Linear mixed models were applied with multivariable adjustment and p-values were corrected for multiple testing. Furthermore, we explored the associations between CRF, PA and two metabolite factors that have previously been linked to risk of Type 2 diabetes. CRF was associated with two phosphatidylcholine clusters independently of all other exposures. Lysophosphatidylcholine C14:0 and methionine were significantly negatively associated with PAEE and sedentary time. CRF was positively associated with the Type 2 diabetes protective factor. Vigorous activity was positively associated with the Type 2 diabetes risk factor in the mutually adjusted model. Our results suggest that CRF and PA are associated with serum metabolites, especially CRF with phosphatidylcholines and with the Type 2 diabetes protective factor. PAEE and sedentary time were associated with methionine. The identified metabolites could be potential mediators of the protective effects of CRF and PA on chronic disease risk. |
| Databáze: | OpenAIRE |
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