Paget's disease of the breast

Autor: Sven J. Kister, Cushman D Haagensen
Rok vydání: 1970
Předmět:
Zdroj: The American Journal of Surgery. 119:606-609
ISSN: 0002-9610
DOI: 10.1016/0002-9610(70)90185-6
Popis: More than a hundred years ago Velpeau first described the nipple lesion we now know as Paget’s disease of the breast. However, it was James Paget who in 1874 observed the association between the nipple erosion and breast cancer. Since then, in almost a century, the pathologic aspects of the disease have been the subject of considerable discussion. There is general agreement today that the Paget cell, first described by Darier in 1889, and seen in the nipple epidermis, is a carcinoma cell invading the epidermis of the nipple and originating from an intraductal carcinoma of the underlying duct system of the nipple or breast. Uncertainty still exists, however, about the clinical behavior of this type of carcinoma and its treatment. Poor over-all survival, even with radical mastectomy, has been reported by Colcock and Sommers [I], Helman and Kliman [2], Maier et al [3], and Kay [4]. These generally unfavorable results are particularly disturbing in view of the fact that Paget’s disease is one of the most slowly evolving forms of cancer. Possible explanations of this paradox may be found in the smallness of the reported series of cases and lack of precise information as to the classification and stage of advancement of the disease. The purpose of this report is to elucidate the behavior of Paget’s disease in correlation with its clinical classification, stage, and pathologic extent in a large series of patients treated uniformly and followed up for a long period of time.
Databáze: OpenAIRE
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