Make Conjugation Simple: A Facile Approach to Integrated Nanostructures
| Autor: | Soubantika Palchoudhury, Yuping Bao, Thomas Macher, Ying Qin, Yaolin Xu |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Nanostructure Surface Properties Dopamine Drug Compounding Nanoparticle Nanotechnology Ferric Compounds Fluorescence Nanoclusters Nanomaterials chemistry.chemical_compound Microscopy Electron Transmission Electrochemistry Animals General Materials Science Particle Size Spectroscopy chemistry.chemical_classification Catechol Biomolecule Water Serum Albumin Bovine Surfaces and Interfaces Condensed Matter Physics Nanostructures Spectrometry Fluorescence chemistry Cattle Gold Iron oxide nanoparticles |
| Zdroj: | Langmuir. 28:8767-8772 |
| ISSN: | 1520-5827 0743-7463 |
| DOI: | 10.1021/la301200g |
| Popis: | We report a facile approach to the conjugation of protein-encapsulated gold fluorescent nanoclusters to the iron oxide nanoparticles through catechol reaction. This method eliminates the use of chemical linkers and can be readily extended to the conjugation of biological molecules and other nanomaterials onto nanoparticle surfaces. The key to the success was producing water-soluble iron oxide nanoparticles with active catechol groups. Further, advanced electron microscopy analysis of the integrated gold nanoclusters and iron oxide nanoparticles provided direct evidence of the presence of a single fluorescent nanocluster per protein template. Interestingly, the integrated nanoparticles exhibited enhanced fluorescent emission in biological media. These studies will provide significantly practical value in chemical conjugation, the development of multifunctional nanostructures, and exploration of multifunctional nanoparticles for biological applications. |
| Databáze: | OpenAIRE |
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