Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl)) in rats
| Autor: | Ying Li, Ting-Ting Fan, Hong Zhang, Quan-Hai Liu, Guoping Wang, Yu Fang |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Hydrocarbons Fluorinated Stereochemistry Glucuronate Antineoplastic Agents Mass Spectrometry chemistry.chemical_compound Glucuronides Tandem Mass Spectrometry Animals Pharmacology (medical) Rats Wistar Benzamide Pharmacology Trifluoromethyl Catabolism Hydrolysis Acetylation Metabolism Rats Metabolic pathway chemistry Female Acid hydrolysis Chromatography Liquid |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 37:45-56 |
| ISSN: | 2107-0180 0378-7966 |
| DOI: | 10.1007/s13318-011-0055-8 |
| Popis: | The metabolism and catabolism of a novel antineoplastic (ID code JS-38),Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5-bis (trifluoromethyl)-(9Cl), were investigated in Wistar rats (3 female, 3 male). LC/UV, LC/MS, LC/MS/MS, NMR and acid hydrolysis methods showed that the metabolic process of JS-38 consists of a series of acetylation and glucoronation that form a metabolic product with a unique pharmacologic property of accelerating bone-marrow cell formation, and also showed a novel metabolic pathway of being acetylated and glucuronated in series. |
| Databáze: | OpenAIRE |
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