Long noncoding RNAs during normal and malignant hematopoiesis
| Autor: | Harvey F. Lodish, Wenqian Hu, Austin A. Gromatzky, Juan R. Alvarez-Dominguez |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Biology, Whitehead Institute for Biomedical Research, Alvarez-Dominguez, Juan R., Lodish, Harvey F., Gromatzky, Austin A. |
| Rok vydání: | 2014 |
| Předmět: |
Regulation of gene expression
medicine.medical_specialty Hematology Disease Biology Hematopoietic Stem Cells Bioinformatics medicine.disease Article Hematopoiesis Blood cell Leukemia Haematopoiesis medicine.anatomical_structure Gene Expression Regulation Hematologic Neoplasms Internal medicine medicine Animals Humans Cell Lineage RNA Long Noncoding Epigenetics Gene |
| Zdroj: | PMC |
| ISSN: | 1865-3774 0925-5710 |
| Popis: | Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies. National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) (Grant DK068348) National Heart, Lung, and Blood Institute (Grant 5P01 HL066105) |
| Databáze: | OpenAIRE |
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