Contribution of capsule endoscopy to Peutz-Jeghers syndrome management in children
| Autor: | Laurent Michaud, Jérôme Viala, Catherine Le Gall, Emmanuel Mas, Alain Dabadie, Chantal Maurage, Swellen Gastineau, Dominique Caldari, E. Darviot |
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| Rok vydání: | 2011 |
| Předmět: |
Enteroscopy
Male medicine.medical_specialty Adolescent Peutz-Jeghers Syndrome Peutz–Jeghers syndrome Capsule Endoscopy law.invention Young Adult Capsule endoscopy law Intussusception (medical disorder) Intestine Small medicine Hamartoma Humans Child Retrospective Studies Hepatology medicine.diagnostic_test business.industry Gastroenterology Capsule Intestinal Polyps Retrospective cohort study medicine.disease Endoscopy Surgery Child Preschool Female business Intussusception Follow-Up Studies |
| Zdroj: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 44(10) |
| ISSN: | 1878-3562 |
| Popis: | Background Capsule endoscopy is recommended for children with Peutz-Jeghers syndrome as young as 8 years of age. Aim of our study was to evaluate the contribution of capsule endoscopy in managing risk of further obstructive complications. Methods A retrospective analysis of 27 children who received at least 1 capsule endoscopy was conducted. Peutz-Jeghers syndrome was diagnosed based on the presence of an STK11 gene mutation or on the association of a hamartoma with 2 of 3 criteria (family history, mucocutaneous pigmentation, small bowel polyposis). Results Thirty-seven capsule endoscopies were performed in 27 patients. The median age at first endoscopy was 11.4 years (range, 5.4–20.9). Jejunal polyps were found in 72% and ileal polyps in 55% of capsules. The original recommendations were followed 20/30 times. Three gastroscopies, 4 colonoscopies, 7 double balloon enteroscopies and 1 intra-operative enteroscopy were performed after the capsules. These procedures revealed jejunal polyps in 9/9 cases (8/9 resected) and ileal polyps in 3/5 (all resected). One intussusception occurred 8.4 months after the capsule endoscopy and required surgical resection. Conclusion Capsule endoscopy is easily feasible in Peutz Jeghers syndrome, but the practice of systematic and repeated procedures needs to be validated prospectively. |
| Databáze: | OpenAIRE |
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