Metabolism of clomipramine in a Japanese psychiatric population: hydroxylation, desmethylation, and glucuronidation
| Autor: | Saburo Takahashi, Kazutaka Shimoda, Morikazu Shibasaki, Toshifumi Noguchi, Toshiyuki Someya, Yuhi Ozeki, Sachiyo Morita |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Clomipramine Adolescent Population Glucuronidation Individuality Nutritional Status Glucuronates Pharmacology Hydroxylation chemistry.chemical_compound Pharmacokinetics Japan Oral administration medicine Humans Drug Interactions Clomipramine Hydrochloride Psychiatry education Biotransformation Aged education.field_of_study Sex Characteristics Chemistry Mental Disorders Smoking Middle Aged Psychiatry and Mental health Dealkylation Female Glucuronide medicine.drug |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 12(4) |
| ISSN: | 0893-133X |
| Popis: | We measured the concentrations of clomipramine and its metabolites, N-desmethylclomipramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine by high-performance liquid chromatography in 108 Japanese psychiatric patients receiving clomipramine hydrochloride PO. The concentrations of the glucuronide conjugates of 8-hydroxyclomipramine and 8-hydroxy-N-desmethyl-clomipramine were assayed via enzymatic hydrolysis. Although there were large interindividual variations of concentrations of parent, intermediate metabolic compounds, and glucuronide conjugates, significant positive correlations were observed between these drug concentrations and daily doses of clomipramine hydrochloride (mg/kg body weight). Although the metabolic ratios for desmethylation, hydroxylation, and glucuronidation that were calculated from steady-state drug concentrations varied substantially with 36-, 14-, and 28-fold interindividual variations, respectively, apparent poor desmethylators, poor hydroxylators, or poor glucuronidators were not found. |
| Databáze: | OpenAIRE |
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