Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases
| Autor: | Jiao-Jing Wang, Sol Misener, Wangqiang Sun, Melina R. Kibbe, Vinayak P. Dravid, Jonathan S. Rink, Zheng Jenny Zhang, Subbu S. Venkatraman, C. Shad Thaxton |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science Apolipoprotein B Phospholipid 02 engineering and technology Nitric Oxide Article Nitric oxide 03 medical and health sciences chemistry.chemical_compound Mice High-density lipoprotein In vivo Biomimetics Animals General Materials Science biology Cholesterol technology industry and agriculture nutritional and metabolic diseases S-Nitrosylation 021001 nanoscience & nanotechnology Atherosclerosis 030104 developmental biology chemistry biology.protein Biophysics Nanoparticles lipids (amino acids peptides and proteins) Nanocarriers 0210 nano-technology Lipoproteins HDL |
| Zdroj: | ACS Appl Mater Interfaces |
| ISSN: | 1944-8252 |
| Popis: | Disorders of blood vessels cause a range of severe health problems. As a powerful vasodilator and cellular second messenger, nitric oxide (NO) is known to have beneficial vascular functions. However, NO typically has a short half-life and is not specifically targeted. On the other hand, high-density lipoproteins (HDLs) are targeted natural nanoparticles (NPs) that transport cholesterol in the systemic circulation and whose protective effects in vascular homeostasis overlap with those of NO. Evolving the AuNP-templated HDL-like nanoparticles (HDL NPs), a platform of bioinspired HDL, we set up a targeted biomimetic nanotherapy for vascular disease that combines the functions of NO and HDL. A synthetic S-nitrosylated (SNO) phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphonitrosothioethanol) was synthesized and assembled with S-containing phospholipids and the principal protein of HDL, apolipoprotein A-I, to construct NO-delivering HDL-like particles (SNO HDL NPs). SNO HDL NPs self-assemble under mild conditions similar to natural processes, avoiding the complex postassembly modification needed for most synthetic NO-release nanoparticles. In vitro data demonstrate that the SNO HDL NPs merge the functional properties of NO and HDL into a targeted nanocarrier. Also, SNO HDL NPs were demonstrated to reduce ischemia/reperfusion injury in vivo in a mouse kidney transplant model and atherosclerotic plaque burden in a mouse model of atherosclerosis. Thus, the synthesis of SNO HDL NPs provides not only a bioinspired nanotherapy for vascular disease but also a foundation to construct diversified multifunctional platforms based on HDL NPs in the future. |
| Databáze: | OpenAIRE |
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