Intratumoral heterogeneity in DNA ploidy of bladder carcinomas
| Autor: | Sanshin Hara, Katsuhiko Hamano, Mitsuru Kinjo, Kohsuke Sasaki |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Cell Aneuploidy Biology Flow cytometry chemistry.chemical_compound Carcinoma medicine Humans Aged Aged 80 and over Carcinoma Transitional Cell Urinary bladder Ploidies medicine.diagnostic_test General Medicine DNA Neoplasm medicine.disease Flow Cytometry medicine.anatomical_structure Transitional cell carcinoma Oncology chemistry Urinary Bladder Neoplasms Ploidy DNA |
| Zdroj: | Oncology. 49(3) |
| ISSN: | 0030-2414 |
| Popis: | In order to investigate whether DNA ploidy in a single area of a tumor could be representative of the entire tumor, flow-cytometric DNA analysis was performed for multiple samples (an average of 7 samples) obtained from the same tumor in 9 cases of transitional cell carcinoma of the urinary bladder. The incidence of DNA aneuploidy was 88.9% (8 out of 9 cases) and, furthermore, in 7 of these, intratumoral regional heterogeneity in DNA ploidy was evident. With high frequency, bladder carcinoma consisted of heterogeneous cell populations with different ploidy. There were 2 cases in which the tumor consisted of mixed subpopulations of diploid and aneuploid clones which were located in different parts of the same tumor. In such cases, an aneuploid line could not have been detected in a single specimen from the tumors. |
| Databáze: | OpenAIRE |
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