Anti-tumor potential of retinoic acid: Stimulation of immune mediated effectors
| Autor: | John Leslie Collins, Gunther Dennert, Paul Q. Patek, Ganesa Yogeeswaran |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Retinoic acid Antineoplastic Agents Tretinoin Stimulation Biology Models Biological Cell Line Mice chemistry.chemical_compound Immune system In vivo Internal medicine medicine Animals Transplantation Homologous Neoplasm Retinoid Mice Inbred BALB C Fetus Chemotherapy Neoplasms Experimental Thymectomy medicine.disease Mice Inbred C57BL Endocrinology Oncology chemistry Cancer research Neoplasm Transplantation |
| Zdroj: | International Journal of Cancer. 24:624-628 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Data are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A × TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymus-dependent immune-mediated effectors able to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition. |
| Databáze: | OpenAIRE |
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