Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults

Autor: Chris Murgatroyd, Nasser Al-Shanti, Mati Pääsuke, M.V. Narici, David A. Jones, Gillian Butler-Browne, Steven Bradburn, Jamie S. McPhee, Lauri Stenroth, Helena Gapeyeva, Sarianna Sipilä, Carel G. M. Meskers, Jean-Yves Hogrel, Liam Bagley, Andrea B. Maier, L Sassano, Y Barnouin, Thomas M. Maden-Wilkinson, Jessica Coulson
Přispěvatelé: Rehabilitation medicine, AMS - Activities and Participation, Manchester Metropolitan University (MMU), Baylor College of Medicine (BCM), Baylor University, Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University of Tartu, Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sheffield Hallam University, Vrije Universiteit Amsterdam [Amsterdam] (VU), University of Melbourne, VU University Medical Center [Amsterdam], University of Nottingham, UK (UON), Unilever Colworth, University of Jyväskylä (JYU), University of Eastern Finland, Neuromechanics, AMS - Ageing and Morbidity
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Aging
osteopontin
senescence
Bone density
[SDV]Life Sciences [q-bio]
Endocrinology
Diabetes and Metabolism
very elderly
Osteoporosis
Body Mass Index
Bone remodeling
chemistry.chemical_compound
Absorptiometry
Photon
0302 clinical medicine
dickkopf 1 protein
fibroblast growth factor 23
osteocalcin
osteoprotegerin
sclerostin
adult
aged
Article
blood sampling
body mass
bone density
bone metabolism
bone remodeling
comparative study
controlled study
diet restriction
disease association
dual energy X ray absorptiometry
female
human
lean body weight
male
osteolysis
priority journal
protein blood level
sex difference
whole body bone mineral density
DKK1
MYOAGE
Osteoprotegerin
Sclerostin
Aged
80 and over
2. Zero hunger
Bone mineral
biology
adult
Europe
Bone Morphogenetic Proteins
Osteocalcin
Intercellular Signaling Peptides and Proteins
Genetic Markers
musculoskeletal diseases
medicine.medical_specialty
Adolescent
030209 endocrinology & metabolism
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
Bone Resorption
Adaptor Proteins
Signal Transducing
business.industry
medicine.disease
Cross-Sectional Studies
030104 developmental biology
Endocrinology
chemistry
Lean body mass
biology.protein
business
Biomarkers
Zdroj: Coulson, J, Bagley, L, Barnouin, Y, Bradburn, S, Butler-Browne, G, Gapeyeva, H, Hogrel, J Y, Maden-Wilkinson, T, Maier, A B, Meskers, C, Murgatroyd, C, Narici, M, Pääsuke, M, Sassano, L, Sipilä, S, Al-Shanti, N, Stenroth, L, Jones, D A & McPhee, J S 2017, ' Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults ', Osteoporosis International, vol. 28, no. 9, pp. 2683-2689 . https://doi.org/10.1007/s00198-017-4104-2
Osteoporosis International, 28(9), 2683-2689. Springer London
Osteoporosis International
Osteoporosis International, 2017, 28 (9), pp.2683-2689. ⟨10.1007/s00198-017-4104-2⟩
ISSN: 0937-941X
1433-2965
DOI: 10.1007/s00198-017-4104-2
Popis: © 2017 International Osteoporosis Foundation and National Osteoporosis Foundation Summary: Bone mineral density declines with increasing older age. We examined the levels of circulating factors known to regulate bone metabolism in healthy young and older adults. The circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin were positively associated with whole-body bone mineral density (WBMD) in older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young. Introduction: This study aims to investigate the relationship between whole-body bone mineral density (WBMD) and levels of circulating factors with known roles in bone remodelling during ‘healthy’ ageing. Methods: WBMD and fasting plasma concentrations of dickkopf-1, fibroblast growth factor-23, osteocalcin, osteoprotegerin, osteopontin and sclerostin were measured in 272 older subjects (69 to 81 years; 52% female) and 171 younger subjects (18–30 years; 53% female). Results: WBMD was lower in old than young. Circulating osteocalcin was lower in old compared with young, while dickkopf-1, osteoprotegerin and sclerostin were higher in old compared with young. These circulating factors were each positively associated with WBMD in the older adults and the relationships remained after adjustment for covariates (r values ranging from 0.174 to 0.254, all p < 0.01). In multivariate regression, the body mass index, circulating sclerostin and whole-body lean mass together accounted for 13.8% of the variation with WBMD in the older adults. In young adults, dickkopf-1 and body mass index together accounted for 7.7% of variation in WBMD. Conclusion: Circulating levels of dickkopf-1, osteocalcin, osteoprotegerin and sclerostin are positively associated with WBMD in community-dwelling older adults, despite the average WBMD being lower and circulating dickkopf-1, osteoprotegerin and sclerostin being higher in old than young.
Databáze: OpenAIRE
Externí odkaz: