Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population
| Autor: | Yanyao Deng, Deren Hou, Mi Tian, Xialu Feng, Weihui Li, Zhuling Yu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Apolipoprotein E Genotype Single-nucleotide polymorphism Neuropsychological Tests Biology Polymorphism Single Nucleotide Asian People Alzheimer Disease Humans SNP Genetic Predisposition to Disease Allele Molecular Biology Genetic Association Studies Aged Aged 80 and over Psychiatric Status Rating Scales Genetics Interleukins Spectrum Analysis General Neuroscience Interleukin-18 Odds ratio Middle Aged Interleukin-33 Genotype frequency Immunology Female Interleukin 18 Neurology (clinical) Interleukin-1 Developmental Biology |
| Zdroj: | Brain Research. 1596:136-145 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2014.11.019 |
| Popis: | Interleukin (IL)-1 plays an important role in Alzheimer׳s disease (AD), and single nucleotide polymorphisms (SNPs) in the IL-1 gene have been shown to be associated with AD susceptibility. IL-18 and IL-33 are proinflammatory cytokines of the IL-1 family, and increasing evidence has accumulated to support their crucial role in AD pathogenesis. To examine whether SNPs in IL-1α (rs1800587), IL-1β (rs1143627), IL-18 (rs187238), and IL-33 (rs11792633) are associated with late-onset Alzheimer׳s disease (LOAD) in a Hunan Han Chinese population, we carried out a case-control study involving 201 LOAD patients and 257 healthy controls. No significant differences were found in genotype frequencies of rs1800587 between LOAD patients and controls ( P =0.079), but the T allele of rs1800587 was associated with a significantly increased risk of LOAD ( P =0.032, odds ratio (OR)=1.592). Significant differences in genotype ( P =0.004) and allele ( P =0.001) frequencies of rs11792633 were found between LOAD patients and controls, but not for rs1143627 ( P =0.535, 0.262, respectively) or rs187238 ( P =0.257, 0.139, respectively). The T allele of rs11792633 was found to be a protective factor for LOAD (OR=0.648). These findings suggest that the IL-1α SNP rs1800587 and IL-33 SNP rs11792633, but not the IL-1β SNP rs1143627 or the IL-18 SNP rs187238, contribute to LOAD susceptibility in the Hunan Han Chinese population. This article is part of a Special Issue entitled SI: Brain and Memory . |
| Databáze: | OpenAIRE |
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