Proteasomes (prosomes) inhibit the translation of tobacco mosaic virus RNA by preventing the formation of initiation complexes
| Autor: | Franck Petit, Susanne Homma, Andrea Horsch, Marie-Noëlle Pouch, Yves Briand, Hans-Peter Schmid |
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| Přispěvatelé: | Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Pélissier, Marie-Noëlle |
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Proteasome Endopeptidase Complex
RNA Transfer Met [SDV]Life Sciences [q-bio] Protein degradation Multienzyme Complexes MHC class I Genetics Protein biosynthesis Tobacco mosaic virus [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Peptide Chain Initiation Translational Molecular Biology biology Cell-Free System RNA Translation (biology) General Medicine Molecular biology Cell biology [SDV] Life Sciences [q-bio] Tobacco Mosaic Virus Cysteine Endopeptidases Kinetics Proteasome Liver Protein Biosynthesis biology.protein RNA Viral Cattle Eukaryotic Ribosome Ribosomes |
| Zdroj: | Molecular Biology Reports Molecular Biology Reports, Springer Verlag, 1994, pp.57-61 Molecular Biology Reports, 1994, pp.57-61 |
| ISSN: | 0301-4851 1573-4978 |
| Popis: | International audience; Proteasomes (prosomes) are large multiprotein complexes. They are involved in protein degradation of ubiquitin-conjugated proteins and in the generation of MHC class I peptides. We gave further evidence that they interfere with in vitro protein synthesis. Proteasomes inhibit the translation of Tobacco mosaic virus RNA. Analysis of cell-free systems by sucrose gradient centrifugation revealed that they prevent the formation of 80S initiation complexes but not the early phase of initiation. |
| Databáze: | OpenAIRE |
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