Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
| Autor: | Min Woo Lee, SunWon Kim, Junyoung Kim, Jeongmoo Han, Joon Woo Song, Hongki Yoo, Jin Won Kim, Hyun Jung Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Risk
Materials science Swine medicine.medical_treatment Science 030204 cardiovascular system & hematology 01 natural sciences Article Optical imaging 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Restenosis 0103 physical sciences medicine Animals Mechanical Phenomena Multidisciplinary medicine.diagnostic_test Spatial filter Helical scan Stent Imaging and sensing Calcinosis Endoscopy Arteries medicine.disease Coronary Vessels Plaque Atherosclerotic Three dimensional imaging Microtechnology Medicine Tomography Rabbits Interventional cardiology Tomography Optical Coherence Coherence (physics) Biomedical engineering |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic µOCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 µm and 3.38 µm in air, respectively. Furthermore, the depth of focus of the µOCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic µOCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic µOCT will be a useful tool for investigating coronary artery disease and stent biology. |
| Databáze: | OpenAIRE |
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