DNAzymes Dz13 target the c-jun possess antiviral activity against influenza A viruses
| Autor: | Shouping Zhang, Sanhu Wang, Zhaopei Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biology Lymphocyte Activation Virus Replication medicine.disease_cause Microbiology Virus Mice 03 medical and health sciences Genes jun Orthomyxoviridae Infections T-Lymphocyte Subsets Cell Line Tumor Influenza A virus medicine Animals Humans c-jun DNA Catalytic Virology Disease Models Animal 030104 developmental biology Infectious Diseases Gene Expression Regulation Viral replication Cell culture Immunology Cytokines Female Viral load CD8 Dz13 |
| Zdroj: | Microbial Pathogenesis. 103:155-161 |
| ISSN: | 0882-4010 |
| DOI: | 10.1016/j.micpath.2016.12.024 |
| Popis: | The emergence of anti-influenza A virus drugs resistant strain highlights the need for more effective therapy. Our earlier study demonstrated that c-jun, a downstream molecule of JNK, might be important in viral infections and inflammatory responses. In the present study, we explored the function of DNAzymes Dz13 that target c-jun in influenza A virus infected mice. Dz13 displayed non-toxic side effects on A549 cells and BALB/c mice. Moreover, Dz13-treated mice had enhanced survival after influenza compared with untreated mice. Simultaneously, the pulmonary inflammatory responses and viral burden were decreased in Dz13 treated mice. Furthermore, proliferation levels of infection-induced CD4+ and CD8+ T cells were impaired. These data demonstrated that Dz13 could reduce viral replication and inflammatory response in vivo, suggesting that Dz13 may potentially be used to treat influenza A viral infection. |
| Databáze: | OpenAIRE |
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