[Toxicity studies of VP 16-213 (III)--Oral six-month chronic toxicity in rats]
| Autor: | Katsumi Ishikawa, Yoshinori Hamajima, Kohji Kuroyanagi, Satoshi Ohta, Norimitsu Takahashi, Toshihito Kadota, Shigeo Kawano, Keiko Ohta, Hisashi Kohmura, Shuichi Kai |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Anemia Administration Oral Bone Marrow Cells Cell Count Thymus Gland Urine Toxicology Eating White blood cell Internal medicine Testis Medicine Animals Chronic toxicity Etoposide Hematologic Tests Testicular atrophy business.industry Body Weight Rats Inbred Strains Organ Size medicine.disease Rats medicine.anatomical_structure Endocrinology Toxicity Erythropoiesis Female medicine.symptom business Emaciation Spermatogenesis |
| Zdroj: | The Journal of toxicological sciences. 11 |
| ISSN: | 0388-1350 |
| Popis: | VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, was administered orally to Crj: CD (Sprague-Dawley) rats of both sexes at dose levels of 1, 3, 10 and 30 mg/kg/day for six months with the object of examining its chronic toxicity and the reversibility of toxic effects. The summarized results obtained are as follows: 1. VP 30 mg/kg suppressed body weight increase and feed intake, and brought transient diarrhea, anemia and depilation. Some animals receiving this dose died showing systemic debility, emaciation and ataxia. 2. VP 3 mg/kg and higher predominantly decreased red blood cell count as well as white blood cell count accompanied with lowered lymphocyte fraction. 3. VP 30 mg/kg lowered total serum protein content and elevated A/G ratio in males, and lowered serum alkaline phosphatase activity in females. 4. VP 10 and 30 mg/kg predominantly induced thymic atrophy, testicular atrophy with suppression of spermatogenesis and tubular atrophy, a decrease in epididymal weight, and splenic erythropoiesis. 5. Above-described changes excluding the findings on testis and epididymis in VP 30 mg/kg group were shown to be generally reversible. Based on these results, the non-effect dose level of VP under the present experimental condition was estimated to be 1 mg/kg/day against rats of both sexes. |
| Databáze: | OpenAIRE |
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