Prediction of local recurrence in colorectal carcinoma: an LDH isoenzymatic assay
| Autor: | E Langvad, B Jemec |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Multiple tumours Colorectal cancer L-Lactate dehydrogenase Biology Resection Tumour tissue medicine Humans In patient Aged L-Lactate Dehydrogenase Rectal Neoplasms Malignant Conversion Middle Aged Prognosis Ldh isoenzymes medicine.disease Isoenzymes Oncology Colonic Neoplasms Female Neoplasm Recurrence Local Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1975.113 |
| Popis: | In a previous study of colorectal carcinoma, the LDH isoenzyme pattern was determined in 420 tissue biopsies from 36 surgical specimens. The LDHIV/LDHII ratio was increased in tumour tissue, but in a number of cases increased ratios were found in the morphologically uninvolved tissue as well. This was especially pronounced in cases with multiple tumours. The isoenzymatic changes were interpreted therefore as a possible indicator of an early process of malignant conversion. In order to test this hypothesis the original material has been reviewed after observation periods ranging from 5 to 7 years. It appears that the mean LDHVI/LDHII isoenzyme ratio of resection edge biopsies is high (0-92) in patients succumbing with local recurrence, differing significantly (P less than 0-01) from the corresponding mean ratio (0-66) in patients clinically cured. |
| Databáze: | OpenAIRE |
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