Plasma renin activity in chagasic patients with and without congestive heart failure
| Autor: | Diego F. Davila, Merched Faddoul, Argenis Torres, Jose H. Donis, Jose C. Gonzalez, Gabriela Arata de Bellabarba, Orlando Figueroa, Carlos J. Vasquez, Antonio M. Khoury |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Chagas Cardiomyopathy Male Cardiac Catheterization medicine.medical_specialty Heart disease medicine.medical_treatment Cardiomyopathy Plasma renin activity Asymptomatic New york heart association Electrocardiography Ventricular Dysfunction Left Internal medicine Renin Renin–angiotensin system medicine Humans Chagas Disease Cardiac catheterization Heart Failure Analysis of Variance business.industry Hemodynamics Middle Aged medicine.disease Heart failure Cardiology Cineangiography Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal of Cardiology. 47:5-11 |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/0167-5273(94)90127-9 |
| Popis: | Chagasic patients with advanced heart disease have fluid retention-dependent symptoms. Since fluid retention is mostly dependent on the renin-angiotensin-aldosterone system, chagasic patients with congestion related symptoms should have activation of the renin-angiotensin-aldosterone system. The purpose of this investigation was to determine the plasma renin activity baseline values of chagasic patients with and without congestive heart failure. Twenty-eight patients with positive serology for Chagas' disease were studied. Nineteen patients were asymptomatic (functional class I New York Heart Association) and nine were symptomatic (functional classes II-IV). Cardiac catheterization and ventricular cineangiography were performed on 20 patients. The symptomatic patients had significantly higher plasma renin activity levels (4.11 +/- 1.03 ng/ml/h) than the asymptomatic patients (1.08 +/- 0.11 ng/ml/h, P0.001) and the normal sedentary controls (1.65 +/- 0.22 ng/ml/h, P0.05, mean +/- S.E.). The plasma renin activity baseline values of the asymptomatic and symptomatic patients correlated directly with the baseline heart rate (r = 0.77, P0.0001). The symptomatic patients had larger ventricular volumes, moderately depressed ejection fractions and increased left ventricular end-diastolic pressures. The plasma renin activity baseline values also correlated directly with the left ventricular diastolic pressures (r = 0.70, P0.0006) and with the left ventricular diastolic (r = 0.66, P0.001) and systolic volumes (r = 0.67, P0.001). These results indicate that chagasic patients with fluid retention-dependent symptoms and hemodynamic evidence of left ventricular systolic dysfunction have activation of the renin-angiotensin-aldosterone system. |
| Databáze: | OpenAIRE |
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