Salicylate release characteristics of selected polyethylene glycol suppositories
| Autor: | Harold W. Puffer, Wilfred J. Crowell |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Base (chemistry)
Chemical Phenomena Surface Properties Kinetics Pharmaceutical Science Polyethylene glycol Suppository Diffusion chemistry.chemical_compound Glycols Organic chemistry chemistry.chemical_classification Chromatography Chemistry Suppositories Sodium Polyethylene Salicylates Sodium salt Solubility Polyethylenes Salicylic acid Mathematics Half-Life |
| Zdroj: | Journal of pharmaceutical sciences. 62(2) |
| ISSN: | 0022-3549 |
| Popis: | Salicylate suppositories were prepared using polyethylene glycol 1540 and polyethylene glycol 6000 in various proportions. The in vitro release of salicylates from each suppository combination was studied using a closed system apparatus designed to circulate fluid about the suppository at 37 ± 0.2°. At scheduled time intervals, samples of the circulating fluid were assayed spectro‐photometrically for salicylate content. Suppositories were also removed from the apparatus, their length and diameter were measured with a vernier caliper, and the change in their surface area was calculated. These surface area changes were then correlated with the salicylate release data. Release of salicylate from the polyethylene glycol suppositories simulated zero‐order kinetics, and the time for 50% release of salicylate ( t ½) from each polyethylene glycol combination did not differ significantly for salicylic acid or its sodium salt. Salicylate release differed markedly for bases composed solely of polyethylene glycol 1540 or 6000; however, when suppositories contained a mixture of the two polyethylene glycols, the rate of release of salicylate approximated that observed for a base composed solely of polyethylene glycol 6000. |
| Databáze: | OpenAIRE |
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