Antileishmanial Activity of Compounds Isolated from Sassafras albidum
| Autor: | Kelly Marie Steinberg, Lianet Monzote, William N. Setzer, Abel Piñón, Divya Pulivarthi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Recrystallization (geology)
Dioxoles Microbial Sensitivity Tests Plant Science Lignans Sassafras chemistry.chemical_compound Sesamin Drug Discovery Trypanocidal agent Leishmania Pharmacology Lignan Sassafras albidum biology Traditional medicine Plant Extracts Chemistry General Medicine Lauraceae biology.organism_classification Sitosterols Trypanocidal Agents Complementary and alternative medicine visual_art visual_art.visual_art_medium Bark Fatty Alcohols |
| Zdroj: | Natural Product Communications. 10:1934578X1501000 |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x1501000723 |
| Popis: | Leishmaniasis is a neglected tropical disease caused by Leishmania parasitic protozoa, which currently lacks efficient treatment. Natural products have shown promise as a potential source for antiprotozoal drugs. This work focuses on the antileishmanial potential of Sassafras albidum (Lauraceae) bark extract. The crude bark extract of S. albidum showed excellent antileishmanial activity with an IC50 value less than 12.5 μg/mL against promastigotes of L. amazonensis. The chloroform stem bark extract of S. albidum was subjected to preparative column chromatography. Five compounds were isolated, purified by recrystallization, and identified as sesamin, spinescin, β-sitosterol, hexatriacontanal, and 1-triacontanol. Antileishmanial and cytotoxic screening were performed on these compounds. Sesamin exhibited the best activity against L. amazonensis with an IC50 of 15.8 μg/mL and was not cytotoxic to mouse macrophage cells ( CC50 > 100 μg/mL). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|