Synthesis of mesocyclic and macrocyclic thiacrown ethers containing -SCH2SCH2S- units using thio(bischloromethane)
| Autor: | Richard M. Kellogg, H. Thijs Stock, J. Buter, J. J. H. Edema |
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| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Thio
Ether Biochemistry Chemical synthesis Chloride chemistry.chemical_compound THIACROWN ETHERS Thionyl chloride 2-THIAPROPANE UNITS Drug Discovery Polymer chemistry medicine Organic chemistry Lewis acids and bases Zinc bromide CYCLIC SULFIDES Chloromethane Organic Chemistry CROWN 14-HEXATHIACYCLOHEXADECANE 16S6 chemistry 1 3 6 9 11 14-HEXATHIACYCLOHEXADECANE 16S6 medicine.drug |
| Zdroj: | Tetrahedron, 48(37), 8065-8072. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0040-4020 |
| Popis: | Oxidative cleavage of 1,3,5-trithiane 1 by the thionyl chloride is promoted by a catalytic quantity of a Lewis acid like zinc bromide or aluminum chloride and results in the formation of pure thiobis (chloromethane) ( 2 ). This reagent has been successfully employed in the straightforward synthesis of a novel series of thiacrown ethers possessing methylene bridges between the heteroatoms. These molecules have chemical and physical properties that differ considerably in their solubilities from those of their ethylenic or propylenic counterparts. |
| Databáze: | OpenAIRE |
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