Transforming choice outcome to action plan in monkey lateral prefrontal cortex: a neural circuit model
| Autor: | Xinying Cai, Xiao Jing Wang, Man Yi Yim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Computer science Decision Making Models Neurological Prefrontal Cortex Fixation Ocular Outcome (game theory) Choice Behavior Article 03 medical and health sciences Neural activity 0302 clinical medicine Saccades Animals General Neuroscience Macaca mulatta 030104 developmental biology Transformation (function) Memory Short-Term Action (philosophy) Action plan Dorsal region Fixation (visual) Female Nerve Net Lateral prefrontal cortex Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| Popis: | In economic decisions, we make a good-based choice first, then we transform the outcome into an action to obtain the good. To elucidate the network mechanisms for such transformation, we constructed a neural circuit model consisting of modules representing choice, integration of choice with target locations, and the final action plan. We examined three scenarios regarding how the final action plan could emerge in the neural circuit and compared their implications with experimental data. Our model with heterogeneous connectivity predicts the coexistence of three types of neurons with distinct functions, confirmed by analyzing the neural activity in the lateral prefrontal cortex (LPFC) of behaving monkeys. We obtained a much more distinct classification of functional neuron types in the ventral than the dorsal region of LPFC, suggesting that the action plan is initially generated in ventral LPFC. Our model offers a biologically plausible neural circuit architecture that implements good-to-action transformation during economic choice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|