Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry
| Autor: | Hiroki Kabata, Risa Watanabe, Takao Mochimaru, Jun Miyata, Koichi Sayama, Takae Tanosaki, Koichi Fukunaga, Koichiro Asano, Yusuke Suzuki, Masako Matsusaka, Shinichi Okuzumi, Katsunori Masaki, M. Kuwae, Kenji Izuhara |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Adult Male medicine.medical_specialty Severe asthma Severity of Illness Index 03 medical and health sciences Therapeutic approach 0302 clinical medicine Japan Internal medicine Observational study Eosinophilic medicine Immunology and Allergy Humans Molecular targeted therapy Public Health Surveillance Registries Treatment Failure Asthma Aged business.industry Disease Management General Medicine Eosinophil Japanese population Middle Aged medicine.disease respiratory tract diseases Clinical trial 030104 developmental biology medicine.anatomical_structure Phenotype Treatment Outcome 030228 respiratory system Population Surveillance Disease Progression Female Symptom Assessment business lcsh:RC581-607 Biomarkers |
| Zdroj: | Allergology International, Vol 70, Iss 1, Pp 61-67 (2021) |
| ISSN: | 1440-1592 |
| Popis: | Background Multiple phenotypes exist within the classification of severe asthma. However, characteristics of patients with not well-controlled severe asthma have not been well identified. Methods Japanese patients with asthma (age ≥ 20 years) were enrolled at the Keio University Hospital and its affiliated hospitals in this observational study (Keio Severe Asthma Research Program). Among them, patients with severe asthma (those undergoing Global Initiative for Asthma [GINA] 2018 step 4 or 5 treatment) were included in this analysis and investigated clinical characteristics based on asthma control status. Results Of the 154 patients (men, 46.8%; age, 60.1 ± 14.9 years), 87 (56.5%) had not well-controlled (partly controlled and uncontrolled) asthma (GINA step 4, 42 patients; step 5, 45 patients). Overall, there were no significant differences in clinical characteristics between patients with well-controlled and not well-controlled asthma. However, cluster analysis revealed that distinct 5 clusters (cluster 1, well-controlled; cluster 2, eosinophilic; cluster 3, non–type 2 inflammation; cluster 4, high periostin; and cluster 5, late-onset type 2 inflammation), and clusters 2–5 were not well-controlled. Among them, cluster 3 was characterized by low eosinophil counts, low periostin levels, and less frequent olfactory disturbance, and this cluster had the worst asthma control. Conclusions Japanese patients with severe asthma were divided into well-controlled and not-well controlled asthma, and we confirmed heterogeneity of not well-controlled severe asthma. These patients, especially non-type 2 phenotype, require a further therapeutic approach. (University Hospital Medical Information Network Clinical Trials Registry, UMIN000002980) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|