Unexpected low expression of platelet fibrinogen receptor in patients with chronic myeloproliferative neoplasms: how does it change with aspirin?
| Autor: | Silvia Carloni, Monica Poggiaspalla, A Augello, Pier Paolo Fattori, Alessandro Lucchesi, Serena De Matteis, Roberta Napolitano, Giulio Giordano, Martina Ghetti, Giovanni Martinelli, Gerardo Musuraca |
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| Přispěvatelé: | Lucchesi A., Carloni S., De Matteis S., Ghetti M., Musuraca G., Poggiaspalla M., Augello A.F., Giordano G., Fattori P.P., Martinelli G., Napolitano R. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Platelets medicine.medical_specialty Fibrinogen receptor aspirin myeloproliferative neoplasm Short Report Fibrinogen myeloproliferative neoplasms Fibrin Flow cytometry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Short Reports Internal medicine medicine Humans Platelet PAC-1 Receptor PAC‐1 Aged Aged 80 and over Aspirin Myeloproliferative Disorders medicine.diagnostic_test biology business.industry platelet fibrinogen receptor food and beverages Hematology Middle Aged humanities Haematological Malignancy‐Biology Endocrinology chemistry 030220 oncology & carcinogenesis Chronic Disease biology.protein business 030215 immunology medicine.drug |
| Zdroj: | British Journal of Haematology |
| Popis: | Summary This study was conducted to evaluate the expression of fibrinogen receptors on platelets of Philadelphia‐negative chronic myeloproliferative neoplasm (MPN) patients. We collected blood samples from 40 consecutive MPN patients and healthy volunteers. We performed flow cytometry analysis of P‐selectin expression and integrin beta‐3, activation of glycoprotein (GP) IIb/IIIa and fibrinogen receptor exposure (PAC‐1 binding). Surprisingly, we found a very low PAC‐1 binding capacity in MPN patients; however, the expression of PAC‐1 was almost completely recovered with aspirin intake. We hypothesize that the hypercoagulable states observed in MPN patients could depend on a primarily plasma‐driven impairment of fibrin turnover and thrombin generation. |
| Databáze: | OpenAIRE |
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